AACR Project GENIE Data
AACR Project GENIE® is a publicly accessible pancancer registry of real-world clinico-genomic data assembled through data sharing among 19 leading international cancer centers. The registry is one of the largest and continuously growing publicly available cancer genomic datasets, with biannual updates. Through strategic partnerships with Sage Bionetworks and cBioPortal, the registry aggregates and harmonizes clinical-grade, next-generation sequencing data from patients treated at participating institutions and makes the data publicly available ensuring they remain accessible to the global cancer research community for the benefit of all.
The AACR Project GENIE® BioPharma Collaborative (BPC) and other sponsored studies link comprehensive clinical data to selected patients from the AACR Project GENIE® Registry. Together, the AACR Project GENIE® registry and the clinically annotated cohorts can be used to accelerate the pace of drug discovery, improve clinical trial design, and advance precision medicine for cancer patients worldwide.
Learn more about how to access AACR Project GENIE® Data.
AACR Project GENIE Registry
AACR Project GENIE® 20.0-public was released in July 2026 and contains more than 289,000 sequenced samples from more than 242,000 patients, making the AACR Project GENIE® Registry among the largest fully public cancer clinico-genomic datasets available. The registry is updated twice annually (January and July) with data from newly sequenced patients contributed by AACR Project GENIE® participating institutions.
- Read the AACR Project GENIE® Overview publication
Coming Soon:
- AACR Project GENIE® 21.0-public (Expected January 2027)
To explore the data, refer to the data guide and the release notes.
Learn more about how to access AACR Project GENIE® Data.
How to Access AACR Project GENIE Data
cBioPortal
- Access AACR Project GENIE® data directly via the cBioPortal platform.
- This handy cBioPortal tutorial will help you navigate through the site.
Synapse
- Download the data directly from the Synapse platform:
Additional Information
- Users will need to create an account for either site and agree to the terms of access.
- For frequently asked questions, visit our FAQ page.
- Training Videos:
AACR Project GENIE BioPharma Collaborative (BPC)
In 2019, AACR Project GENIE® launched a multi-year pre-competitive research collaboration with a coalition of ten biopharmaceutical companies to create The AACR Project GENIE® BioPharma Collaborative (BPC), aimed at adding in-depth, longitudinal, clinical data to approximately 20,000 patients from the AACR Project GENIE® Registry.
- Read the GENIE® BPC Project Overview publication
Phase 1
In years one and two, the project deeply clinically annotated nearly 8,000 patients with lung, colorectal, early-onset breast, pancreatic, prostate, and bladder cancers treated at Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, Princess Margaret Cancer Center, and Vanderbilt-Ingram Cancer Center.
Available Now:
- NSCLC 2.0-public
- CRC 2.0-public
- BRCA 1.0-public
- PANC 1.0-public
- Prostate 1.0-public
- Bladder 1.0-public
An R package for analyzing these data, {genieBPC}, is available at the following sources:
- CRAN
- GitHub
- Read about how to use the package.
Phase 2
In years three through six, data collection expanded to include additional patients with lung and colorectal cancers, as well as patients with cutaneous melanoma and kidney, ovarian, and esophagogastric cancers. Data were contributed by Phase 1 institutions and three additional centers: the Sidney Kimmel Cancer Center at Johns Hopkins University, Providence Cancer Institute, and Vall d’Hebron Institute of Oncology. Data will be publicly available as the two-year embargo expires on each cohort.
Learn more about how to access AACR Project GENIE® Data.
AACR Project GENIE Sponsored Study Projects
Sponsored Study Projects are customized data collaborations between AACR Project GENIE® and any partner needing real-world clinico-genomic data. These projects incorporate additional in-depth, longitudinal clinical data with existing information on selected patients within the AACR Project GENIE® Registry tailored to sponsor-defined research questions.
Available Data:
- AACR Project GENIE AKT1 Cohort: 428 breast cancer patients with AKT1 E17K mutations
- ERBB2 Cohort: 135 breast cancer patients with select ERBB2 mutations