AACR Project GENIE
Driven by openness, transparency, and inclusion, AACR Project GENIE® (Genomics Evidence Neoplasia Information Exchange) is a publicly accessible cancer registry of real-world clinico-genomic data assembled through data sharing between leading international cancer centers. Through the efforts of strategic partners Sage Bionetworks and cBioPortal, the registry aggregates, harmonizes, and links clinical-grade, next-generation cancer genomic sequencing data with clinical outcomes obtained during routine medical practice from nearly every cancer patient sequenced at these institutions.
Why GENIE?
Precision medicine requires an end-to-end learning health care system, wherein the treatment decisions for patients are informed by the prior experiences of similar patients. Oncology is currently leading the way in precision medicine because the genomic and other molecular characteristics of patients and their tumors are routinely collected at scale. A major challenge to precision medicine is that no single institution is able to sequence and treat sufficient numbers of patients to improve clinical-decision making independently. To overcome this challenge, Charles L. Sawyers of Memorial Sloan Kettering Cancer Center, conceptualized GENIE in 2014. The AACR subsequently developed and launched Project GENIE in 2015.