AACR Project GENIE Registry
The AACR Project GENIE Registry was first made available to the global research community in January 2017. Our most recent release, GENIE 17.0-public, was published in January 2025. The registry now includes approximately 229,000 sequenced samples from over 196,000 patients, making AACR Project GENIE one of the largest fully public cancer genomic datasets available to date.
Data is collected from nearly every patient sequenced at participating institutions, all of which are committed to sharing only clinical-grade data. This ensures that the GENIE registry contains high-quality information, crucial for driving informed decision-making in the study of rare cancers and rare variants in common cancers. By providing a robust knowledge base, GENIE accelerates the drug discovery process, enhances clinical trial design, and ultimately contributes to better outcomes for cancer patients worldwide.
The GENIE Registry is updated biannually (in January and July) to include new patients and samples, and real-world clinical data linked to next-generation sequencing results from patients treated at GENIE participating institutions.
To explore the data, refer to the data guide and the release notes.
In addition to the main registry, Project GENIE also includes additional cohorts that provide deeper clinical annotation for patients within the Main GENIE registry. These datasets offer more detailed clinical information, such as treatment regimens, response assessments, and survival outcomes, further enhancing the ability to study real-world cancer treatments and outcomes.
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GENIE BioPharma Collaborative (BPC)
In 2019, AACR Project GENIE launched a five-year research collaboration, The Biopharma Collaborative (BPC), with a coalition of ten biopharmaceutical companies with the goal of obtaining clinical and genomic data from an estimated 50,000 de-identified patients treated at the institutions participating in AACR Project GENIE. The additional clinical data collected as part of the BPC furthers the goals of advancing precision oncology and powering clinical decision-making through open and transparent data sharing.
See our biopharmaceutical collaborators.
In the first two years, Phase 1, the project added prior cancer treatments, tumor pathology, and clinical outcomes to the clinical data already linked with the genomic profiles of nearly 8,000 lung, colorectal, breast, pancreatic, prostate, and bladder cancer patients treated at Dana-Farber Cancer Institute, Memorial Sloan Kettering Cancer Center, Princess Margaret Cancer Center, and Vanderbilt-Ingram Cancer Center.
BPC Phase 1 Cohorts
Available Now:
- NSCLC 2.0-public: 1,846 non-small cell lung cancer patients
- CRC 2.0-public: 1,485 colorectal patients
Coming Soon:
- BRCA 1.0-public [add more details]
- PANC 1.0-public [add more details]
- Prostate 1.0-public [add more details]
- Bladder 1.0-public [add more details]
In years three through five, Phase 2, data collection will be expanded to additional cancer types from additional participating institutions.
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GENIE Sponsor Study Projects
Sponsor Study Projects are customized data collaborations between Project GENIE and pharmaceutical, biotech, or diagnostic companies. These projects leverage the full scope of the GENIE registry, including both genomic and clinical data, to support sponsor-defined research questions. Upon publication, these projects are made available publicly:
Available Now:
- AACR Project GENIE AKT1 Cohort: [add more details]
- ERBB2 Cohort (GENIE, 2022): [add more details]
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Additional GENIE Projects
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Available Now:
- DFCI-Profile Glioma Cohort 2013-2018 (DFCI, Nat Med.2020): [add more details]
- Metastatic Breast Cancer: 2013-2016 (DFCI, CCR 2020): [add more details]
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For more information about accessing the data, visit our Data Access page.
For more information about Project GENIE, visit our FAQ page.
Last Updated: July 7, 2025